Laser desorption ionization mass spectrometric imaging of mass barcoded gold nanoparticles for security applications.

Mass Spectrometric Detection of Nanoparticle Host–Guest Interactions in Cells

Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates ...

Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis

Semiconductor quantum dots (QDs) or nanoparticles (NPs) exhibit very unusual physico-chemcial and optical properties. This review article introduces the applications of semiconductor nanomaterials (NMs) in fluorescence spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for biomolecule analysis. Due to their unique physico-chemical and optical properties, s...

Nanoparticles for Selective Laser Desorption/Ionization in Mass Spectrometry

The selective desorption/ionization of analytes using nanomaterials is investigated using metallic nanoparticles. By replacing the sodium citrate capping of gold nanoparticles with self-assembled monolayers, we are able to both enhance analyte ionization and selectively capture analytes. Capping gold nanoparticles with a monolayer of 4-mercaptobenzoic acid enhances analyte ionization while grea...

Comparison of NIMS and MALDI platforms for neuropeptide and lipid mass spectrometric imaging in C. borealis brain tissue.

Nanostructure-initiator mass spectrometry (NIMS) is a recently developed matrix-free laser desorption/ionization technique that has shown promise for peptide analyses. It is also useful in mass spectrometric imaging (MSI) studies of small molecule drugs, metabolites, and lipids, minimizing analyte diffusion caused by matrix application. In this study, NIMS and matrix-assisted laser desorption/i...

TABLE OF CONTENTS 3 HIGH RESOLUTION MASS SPECTROMETRIC IMAGING USING LASER DESORPTION/IONIZATION DROPLET DELIVERY MASS SPECTROMETRY AND NANOAMBIENT IONIZATION MASS SPECTROMETRY - - - Jae Kyoo Lee and Samuel Kim 4 DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRY IMAGING IN BIOMEDICAL RESEARCH